His remarks in a meeting with Air Force personnel in Tehran on Friday came hours after the US imposed its first sanctions in the wake of President Donald Trump’s signing of an order to reimpose his “maximum pressure” on Iran.
"Negotiations with the US have no effect on solving the country's problems, we must get this right," Ayatollah Khamenei said, citing the withdrawal from a nuclear deal with Iran by the Americans.
"They should not pretend to us that if we sit at the negotiating table with that government, the problems will be solved. No; negotiating with the US will not solve any problems. The reason? Experience!"
In 2015, Iran and six other countries, including the US, signed the now-dormant Joint Comprehensive of Plant of Action (JCPOA) after two years of negotiations, only to be discarded by President Trump.
Ayatollah Khamenei recalled the grueling back and forth, which included a 15-minute stroll by then-US Secretary of State John Kerry and Mohammad Javad Zarif in downtown Geneva and along the Rhone River which landed the former Iranian foreign minister in hot water.
“Our government at the time sat down and negotiated - they continued to come and go, they sat down and stood up and negotiated, they talked, laughed, shook hands, made friends, everyone worked, and a treaty was formed.
"In this treaty, the Iranian side was very generous, giving many concessions to the other side. But the Americans did not implement the same treaty," the Leader said.
"The same person who is in office now tore up the treaty. He said he would tear it down and he did; they didn't act upon" the agreement, he said, referring to Trump.
Neither did the successors of the Trump administration implement the agreement, Ayatollah Khamenei added.
“The treaty was meant to lift US sanctions, but they were not lifted. Adding insult into injury, they had the UN to have a constant threat hanging over Iran. This treaty was the product of negotiations that lasted about two years.”
Iran is currently in the midst of celebrations marking the anniversary of the Islamic Revolution which sealed the fate of the US-backed Pahlavi regime in 1979.
Every year on February 8, Iranian Air Force personnel meet the Leader to relive the historic allegiance of Air Force officers with the late founder of the Islamic Republic Imam Khomeini in 1979. The event is viewed as a turning point which led to the victory of the Islamic Revolution three days later.
Ayatollah Khamenei watches as Iranian Air Force personnel salute him during a meeting in Tehran Friday.
Ayatollah Khamenei said the Americans are busy working “on paper to change the map of the world”, with Iran also being the subject of their plans.
“Of course, it's only on paper, it has no reality. They also talk about us, make comments, and threaten us," the Leader said.
Ayatollah Khamenei said, “If they threaten us, we will threaten them. If they put their threat into practice, we will do the same. If they attack the security of our nation, we will attack their security without hesitation."
“This is a lesson taken from the Qur’an and the teachings of Islam, and it is our duty to act as such. We hope that God Almighty will make us successful in carrying out our duties," he added.